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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
20
Human Site:
S292
Identified Species:
36.67
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
S292
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
N339
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
S292
E
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
S292
A
D
F
V
D
F
T
S
Q
C
L
K
K
N
S
Rat
Rattus norvegicus
Q4KSH7
419
47517
V357
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
A308
P
E
F
V
D
F
T
A
Q
C
L
R
K
N
P
Chicken
Gallus gallus
Q90891
398
44059
N345
Q
D
F
Q
E
F
V
N
K
C
L
I
K
N
P
Frog
Xenopus laevis
Q07192
446
50082
S389
E
F
S
P
S
F
T
S
F
V
N
Q
C
L
T
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S319
A
D
F
V
D
F
T
S
Q
C
L
R
K
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
A285
P
E
F
E
D
F
I
A
V
C
L
Q
K
E
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
I307
S
L
P
L
V
K
F
I
N
T
C
L
T
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
S308
P
E
L
S
S
F
I
S
T
C
L
Q
K
D
P
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
S601
S
D
A
Q
D
F
V
S
L
C
L
Q
K
I
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
53.3
N.A.
93.3
N.A.
93.3
0
N.A.
73.3
40
20
86.6
N.A.
46.6
N.A.
0
N.A.
P-Site Similarity:
100
66.6
N.A.
93.3
N.A.
100
13.3
N.A.
86.6
66.6
33.3
100
N.A.
60
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
8
0
0
0
0
16
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
77
16
0
8
0
0
% C
% Asp:
0
31
8
0
62
0
0
0
0
8
0
0
0
8
16
% D
% Glu:
16
47
0
8
8
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
8
62
8
0
85
16
0
8
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
16
8
0
0
0
16
0
8
0
% I
% Lys:
0
0
0
0
0
8
0
0
24
0
0
24
77
16
0
% K
% Leu:
8
8
8
8
0
0
0
0
8
0
77
16
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
16
8
0
8
0
0
54
0
% N
% Pro:
24
0
8
8
0
0
0
0
0
0
0
0
0
0
39
% P
% Gln:
8
0
0
24
8
0
0
0
39
0
0
31
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% R
% Ser:
24
0
8
8
16
8
0
54
0
0
0
0
0
0
31
% S
% Thr:
0
0
0
0
0
0
47
0
8
8
0
0
16
0
8
% T
% Val:
0
0
0
39
8
0
24
8
8
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _